General toxic and cardiovascular toxic impact of cadmium oxide nanoparticles

Introduction. Non-ferrous smelters are one of the critical nanoscale cadmium particles sources in workplace and ambient air. Materials methods. The research was performed to evaluate subchronic toxicity oxide nanoparticles (CdO-NPs) white outbred rats. Male 3.5-month old rats received intraperitoneal injections CdO-NPs 3 times a week for six weeks (18 total) doses 0.25 mg/kg body mass. After end an exposure, there were rated more than 50 indices universally accepted criteria (including biochemical cytomorphometric). Student’s t-test used statistical analysis. Results. hematotoxic effects revealed by decrease hemoglobin content, increase number reticulocytes, eosinophils, monocytes. CdO NPs influenced porphyrin metabolism (an δ-aminolevulinic acid urine). Liver resulted organ mass albumin content A/G index. Besides, observed rise γ-glutamyl transpeptidase high-density lipoproteins blood serum. Oxidative stress level increased (decrease catalase action ceruloplasmin content). Endothelin-1 decreased. It may result from pressure (statistically significant mean B.P.). Conclusion. intoxication moderate severity retrieved at exposure nanoparticles. characterized mass, hematological, biochemical, cytomophometric changes. There found mild but evident cardiovascular